Cagrilintide 5mg

Description

Cagrilintide is a long-acting amylin analog with published obesity and diabetes trial data, including combination development programs with semaglutide.

What it is

Cagrilintide is a long-acting amylin analog in active metabolic-disease development, with published obesity/diabetes trial data and ongoing late-stage programs.

Mechanism snapshot

• Targets amylin-pathway signaling involved in appetite and energy-balance regulation.
• Investigated as monotherapy and in coadministration with semaglutide (CagriSema) for weight and glycemic endpoints.
• Studied for efficacy durability, tolerability, and cardiometabolic-risk impact.

Research programs

• Phase 1b and phase 2 weight-management trials.
• Late-stage registry programs in obesity and type 2 diabetes populations.
• Comparative and long-horizon maintenance-of-effect investigations.

Limitations

• Full late-stage synthesis is still evolving and status can change.
• Comparative efficacy interpretation depends on protocol and population context.
• Long-term safety and indication-specific labeling remain development-dependent.

Selected references

• Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial - PubMed 2021
• Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2?4 mg for weight management: a randomised, controlled, phase 1b trial - PubMed 2021
• Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity - PubMed 2025
• REDEFINE 1: A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight (NCT05567796) - ClinicalTrials.gov Status snapshot
• REDEFINE 4: Long-term CagriSema Weight Loss and Maintenance Study (NCT07011667) - ClinicalTrials.gov Status snapshot

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